![]() ![]() At the same time, their rigidity provides structural integrity to cells and provides passageways between cells, allowing for cell migration. GAGs are located primarily on the surface of cells or in the extracellular matrix (ECM) but are also found in secretory vesicles in some types of cells.Īlong with the high viscosity of GAGs comes low compressibility, which makes these molecules ideal for a lubricating fluid in the joints. GAGs are highly negatively charged molecules, with extended conformation that imparts high viscosity to the solution in which they reside. The disaccharide units contain either of two modified sugars, N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc), and a uronic acid such as glucuronate (GlcA) or iduronate (IdoA) or a galactose residue. The GAG molecules are long unbranched polysaccharides containing a repeating disaccharide unit. The glycosaminoglycans are historically referred to as the mucopolysaccharides given that they were originally characterized in mucus membranes and mucosal exudates. The most abundant heteropolysaccharides in the body are the glycosaminoglycans (GAGs). Pathways of Keratan Sulfate Degradation.Pathways of Heparan/Heparin Sulfate Degradation.Pathways of Dermatan Sulfate Degradation.Clinical Significance of Glycosaminoglycan Degradation.Clinical Significance of Tetrasaccharide Linker Synthesis.Table of the Representative Mammalian Proteoglycan Types. ![]() Synthesis of the Tetrasaccharide Linker in Proteoglycans.Carbohydrate Sulfation in Glycosaminoglycans.Table of the Glycosaminoglycan Disaccharides. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |